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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MLL3 All Species: 16.36
Human Site: T3298 Identified Species: 60
UniProt: Q8NEZ4 Number Species: 6
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8NEZ4 NP_733751.2 4911 541370 T3298 I P G A T P P T M S Q P T F P
Chimpanzee Pan troglodytes XP_519508 4802 529408 T3240 I P G A T P P T M S Q P A F P
Rhesus Macaque Macaca mulatta XP_001107669 4824 532391 T3090 I P G A T P P T M S Q P S F P
Dog Lupus familis XP_853821 1445 159157
Cat Felis silvestris
Mouse Mus musculus Q8BRH4 4903 540168 T3294 V P G A T S L T M S Q P N F P
Rat Rattus norvegicus XP_002726356 4931 542751 T3319 V P G A S P L T M S Q P N F P
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q8IRW8 2431 259810 Q970 Q L Q P S P H Q V K Q T V Q I
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 94.9 92.2 26.2 N.A. 85.3 84.3 N.A. N.A. N.A. N.A. N.A. N.A. 21 N.A. N.A. N.A.
Protein Similarity: 100 95.5 93.1 27.5 N.A. 90.7 89.7 N.A. N.A. N.A. N.A. N.A. N.A. 31.9 N.A. N.A. N.A.
P-Site Identity: 100 93.3 93.3 0 N.A. 73.3 73.3 N.A. N.A. N.A. N.A. N.A. N.A. 13.3 N.A. N.A. N.A.
P-Site Similarity: 100 93.3 100 0 N.A. 80 86.6 N.A. N.A. N.A. N.A. N.A. N.A. 26.6 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 72 0 0 0 0 0 0 0 0 15 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 72 0 % F
% Gly: 0 0 72 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 15 0 0 0 0 0 0 0 0 % H
% Ile: 43 0 0 0 0 0 0 0 0 0 0 0 0 0 15 % I
% Lys: 0 0 0 0 0 0 0 0 0 15 0 0 0 0 0 % K
% Leu: 0 15 0 0 0 0 29 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 72 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 29 0 0 % N
% Pro: 0 72 0 15 0 72 43 0 0 0 0 72 0 0 72 % P
% Gln: 15 0 15 0 0 0 0 15 0 0 86 0 0 15 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 29 15 0 0 0 72 0 0 15 0 0 % S
% Thr: 0 0 0 0 58 0 0 72 0 0 0 15 15 0 0 % T
% Val: 29 0 0 0 0 0 0 0 15 0 0 0 15 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _